Pyeloplasty in Infants

December 15, 2025 By Dr. Ashish Prasad

Pyeloplasty in Infants

Restoring Kidney Function in Infants: A Case Study on Early Pyeloplasty for PUJ Obstruction

For expecting parents, the joy of pregnancy is sometimes clouded by the anxiety of an unexpected diagnosis. One of the most common abnormalities detected during antenatal ultrasounds is Hydronephrosis—swelling of the kidney due to a build-up of urine. While many of these cases resolve on their own, some represent a significant blockage that threatens the long-term health of the child's kidney.

This article details a recent success story from our clinic involving a 1-month-old infant referred from Rajasthan. It serves as a testament to the power of early evaluation and timely surgical intervention in congenital renal conditions.

The Case Presentation: A Referral from Rajasthan

We recently managed the care of a baby, just 1 month and 20 days old, who was referred to us from a small town in Rajasthan. The journey began long before the baby was born, with an antenatal diagnosis of Right Hydronephrosis.

Post-natal follow-up is crucial in these antenatal cases to determine if the swelling is transient or if it represents a true obstruction. In this case, the condition was not resolving.

Clinical Evaluation Findings: Upon presentation, the infant underwent a rigorous evaluation to determine the severity of the condition. The findings were concerning:

  • Persistent Gross Hydronephrosis:The swelling in the right kidney was significant and persistent.
  • Anterior-Posterior Diameter (APD):The renal pelvis measured an APD of 28 mm. In the world of pediatric urology, an APD greater than 15-20mm is considered severe and highly indicative of significant pathology.
  • Parenchymal Thinning: The pressure from the trapped urine was pushing against the kidney wall, causing the renal parenchyma (the functional tissue of the kidney that filters blood) to thin out. This is a red flag, indicating that the kidney is under stress and losing potential functional mass.

The Functional Scan (EC Scan): To understand not just the anatomy but the function of the kidney, an EC (Ethylene Cysteine) scan was performed. This nuclear medicine scan provides a "Split Renal Function" (SRF) percentage, comparing the left kidney to the right.

  • Diagnosis: Right Pelvi-ureteric Junction (PUJ) Obstruction.
  • Function: The right kidney showed impaired drainage and a split renal function of close to 40%. While 40% is not a "dead" kidney, it is below the normal range (which should be roughly 50% for each kidney), indicating that the obstruction was already hindering the organ's performance.

Understanding PUJ Obstruction

Pelvi-ureteric Junction (PUJ) Obstruction is a blockage at the point where the kidney pelvis connects to the ureter (the tube that carries urine to the bladder). When this junction is narrow or kinked, urine cannot drain freely. It backs up into the kidney, causing:

  • Hydronephrosis: Dilation/swelling of the collection system.
  • Pressure Atrophy: High pressure destroys the delicate filtering units (nephrons) of the kidney.
  • Infection Risk: Stagnant urine is a breeding ground for bacteria, leading to pyelonephritis (kidney infection).

In this specific case, the "tight" nature of the obstruction was evidenced by the significant APD of 28mm and the drop in function to 40%.

The Treatment Dilemma: Observation vs. Early Intervention

One of the most debated topics in pediatric urology is the timing of surgery for antenatally diagnosed PUJO. Generally, two schools of thought exist in the medical community:

  • The Conservative Approach (Wait and Watch)This school of thought suggests observing the infant initially with serial ultrasounds and scans. The rationale is that some dilations improve over time as the kidney matures. Surgeons favoring this approach reserve Pyeloplasty(surgical repair) only when there is documented deterioration in function (e.g., dropping from 40% to 30%) or worsening symptoms like recurrent infections or pain.
  • The Early Intervention ApproachThe second school of thought—and the one applied in this case—advocates for early correction to ensure maximal recovery. The logic here is preventative: why wait for the kidney to lose function before saving it? Infants possess a remarkable degree of "renal plasticity," meaning their developing kidneys have a unique ability to heal and grow if the pressure is relieved early.

Our Decision: Given the APD of 28mm, the thinning parenchyma, and the already reduced function (40%), "watching and waiting" posed a significant risk of permanent kidney damage. We decided to proceed with surgery to give this baby the best chance at a normal life.

The Procedure: Right Pyeloplasty

The baby was admitted to Stephens Hospital in March of this year. The chosen procedure was a Right Pyeloplasty.

What is a Pyeloplasty? Pyeloplasty is a reconstructive surgery. The goal is not just to remove the blockage, but to remodel the drainage system. During the surgery, the narrowed segment of the PUJ is excised (removed). The healthy ureter is then stitched back to the healthy renal pelvis to create a wide, funnel-shaped channel that allows gravity to easily drain the urine.

In infants, this is a delicate procedure requiring precision, as the structures are tiny. However, when performed by experienced hands, it is highly effective with low morbidity.

The Outcome: A "Miracle" Recovery

The true measure of success in surgery is not just a technically good operation, but the long-term functional outcome for the patient.

The baby returned for a follow-up assessment at 7 months post-operation. The results were nothing short of excellent and validated the decision to operate early.

Ultrasound Findings:The massive swelling had resolved. The ultrasound showed only "minimal right-side PCS (Pelvicalyceal System) swelling." The pressure on the kidney was gone, and the thinning of the parenchyma had halted.

Functional Recovery (The EC Scan):This is the most critical metric. The repeat EC scan showed:

  • Drainage: Normal (no obstruction).
  • Function: Significant improvement in split renal function to 50%.

Why is 50% significant? We have two kidneys. In a perfectly healthy human body, each kidney does exactly half the work (50/50 split). Before surgery, this baby's right kidney was lagging at 40%. After surgery, it recovered fully to 50%. This indicates a complete normalization of kidney function. The kidney is now growing and filtering exactly as it should, indistinguishable in performance from the healthy left kidney.

Comparative Analysis: Pre-Op vs. Post-Op

The table below summarizes the dramatic turnaround in this infant’s health:

Clinical Parameter Pre-Operative Status (1 Month Old) Post-Operative Status (7 Months Follow-up)
Diagnosis Gross Hydronephrosis with PUJ Obstruction

Resolved Obstruction

APD Measurement 28 mm (Severe) Minimal / Insignificant
Renal Parenchyma Thinning observed Pressure relieved, growth enabled
Drainage Pattern Obstructed Normal Drainage
Split Renal Function ~40% (Impaired) 50% (Normal/Perfect)

Discussion: Why Early Surgery Works

This case adds to the growing body of evidence supporting early infant pyeloplasty. Numerous studies have proven that:

  • High Success Rate: Infant pyeloplasty has a success rate exceeding 95% in expert hands.
  • Better Recovery: Post-pyeloplasty functional recovery is demonstrably better when performed at an earlier age (1–3 months).
  • Renal Reserve: Early surgery taps into the "renal functional reserve." By relieving the high pressure early, we allow the nephrons (kidney filters) to mature normally. If we wait until the child is older, the kidney may develop scar tissue (fibrosis) that is irreversible, even if the blockage is eventually removed.

In this case, waiting could have resulted in the function dropping below 35% or 30%. Recovering from that deficit is much harder than recovering from 40%. The leap from 40% back to a perfect 50% highlights the incredible healing power of the infant body when given the right help at the right time.

Message to Parents

Receiving a diagnosis of hydronephrosis or kidney obstruction in your newborn is frightening. You may feel overwhelmed by medical terms like "APD," "parenchymal thinning," and "split function."

However, modern pediatric urology offers hope and definitive cures.

  • Don't ignore the diagnosis: Even if the baby looks healthy on the outside, the kidneys may be under pressure on the inside.
  • Seek specialized care: Evaluation with detailed ultrasounds and nuclear scans (EC scans) is vital.
  • Trust the timing: While avoiding surgery is always a goal, timely surgery is a cure. As this case from Rajasthan proves, early intervention can completely reverse damage and lead to a life of normal kidney health.

This baby, once facing the threat of kidney damage, is now growing up with two perfectly functioning kidneys, thanks to the vigilance of the parents and timely surgical intervention at Stephens Hospital.